In the realm of mental health treatment, antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) like sertraline, have been pivotal in managing depression and anxiety disorders.

However, a recent case report and literature review by Ji Yang, Yi Ying, Liying Jin, Fei Ying, Junwei Fang, Xuyong Chen, Mengying Zhu, and Xingyi Yang have brought to light a rare but significant side effect of sertraline that warrants attention: acute pancreatitis.

What is Acute Pancreatitis?

Acute pancreatitis is a sudden inflammation of the pancreas, a gland behind the stomach that plays a crucial role in digestion and regulating blood sugar. This condition can range from mild discomfort to a severe, life-threatening illness.

The severity of acute pancreatitis can vary, manifesting as a self-limiting condition that resolves with minimal treatment or as a more severe form that can lead to complications and require intensive care.


The most common causes of acute pancreatitis include:

  • Gallstones: These can block the pancreatic duct, leading to inflammation.
  • Alcohol consumption: Heavy or prolonged alcohol use is a significant risk factor.
  • Medications: Certain drugs can induce pancreatitis as a side effect.
  • High triglyceride levels: Extremely high levels of triglycerides in the blood can lead to pancreatitis.
  • Abdominal injury: Trauma to the abdomen can cause inflammation of the pancreas.
  • Other causes include infections, surgical procedures, and certain conditions like cystic fibrosis.


Symptoms of acute pancreatitis may include:

  • Severe abdominal pain: Often starting in the upper abdomen, which may radiate to the back. The pain may worsen after eating and can be constant and severe.
  • Nausea and vomiting
  • Fever
  • Rapid pulse
  • Swollen and tender abdomen

Understanding Sertraline

Sertraline, marketed under various brand names such as Zoloft, is a widely prescribed antidepressant belonging to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs).

It is used to treat a range of mental health conditions, including major depressive disorder, anxiety disorders (such as panic disorder, social anxiety disorder, and post-traumatic stress disorder), obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD).

How Sertraline Works

Sertraline works by influencing the neurotransmitters in the brain, specifically targeting serotonin. Neurotransmitters are chemical messengers that allow nerve cells (neurons) to communicate with each other.

Serotonin is one such neurotransmitter that is involved in regulating mood, anxiety, and happiness, among other functions.

Under normal circumstances, once serotonin is released into the synaptic cleft (the gap between two nerve cells), it binds to receptors on the receiving neuron, transmits its message, and is then reabsorbed by the releasing neuron in a process called reuptake.

Sertraline works by inhibiting the reuptake of serotonin back into the nerve cell that released it. This action increases the serotonin available in the synaptic cleft, enhancing neurotransmission and improving mood and emotional state.

Clinical Use

Sertraline is typically taken orally, once daily, with or without food. The dosage and duration of treatment depend on the condition being treated, the severity of symptoms, and individual patient factors.

It may take several weeks or longer to notice an improvement in symptoms, which is common with SSRIs.

Side Effects

Like all medications, sertraline can cause side effects, although not everyone experiences them. Common side effects include nausea, headaches, sleep disturbances, fatigue, dry mouth, and sexual dysfunction.

Most side effects are mild to moderate and diminish as the body adjusts to the medication. However, any persistent or bothersome side effects should be discussed with a healthcare provider.

The Case of a Teenager’s Struggle with Sertraline-Induced Acute Pancreatitis

The report details the distressing experience of a 15-year-old male teenager with a history of depression who developed acute pancreatitis following a self-overdose of his sertraline prescription.

Presenting symptoms included abdominal pain, nausea, and vomiting—common indicators of acute pancreatitis but often mistaken for less severe conditions.

With the exclusion of typical causes such as alcohol consumption, gallstones, and others, the diagnosis was supported by elevated amylase levels and computed tomography findings showing parenchymal edema of the pancreas.

Fortunately, after discontinuing sertraline and receiving conventional treatment for acute pancreatitis, the teenager recovered smoothly.

Sertraline and Drug-Induced Pancreatitis: A Rare Association

Drug-induced pancreatitis (DIP), though accounting for less than 3% of acute pancreatitis cases, is increasingly recognized as a critical etiology of this condition.

The association between SSRIs like sertraline and acute pancreatitis, particularly in cases of overdose, is rare but vital for clinicians and patients to be aware of.

This case underscores the importance of monitoring for potential adverse effects, even with medications generally considered safe at recommended doses.

Implications for Clinicians and Patients

Implications for Clinicians and Patients - Safe Therapeutics

This report serves as a crucial reminder of the need for vigilance when prescribing and using antidepressant medications, especially in younger patients. Clinicians should:

  • Be mindful of the rare but possible risk of acute pancreatitis with SSRIs.
  • Educate patients and their families about the importance of adhering to prescribed doses.
  • Advise on the signs and symptoms of acute pancreatitis to ensure prompt recognition and treatment.

Patients, on their part, should:

  • Strictly follow their medication regimen and consult their doctor before making any changes.
  • Be aware of the symptoms of acute pancreatitis and seek immediate medical attention if they experience severe abdominal pain, nausea, or vomiting.

Conclusion: A Call for Awareness and Caution

While SSRIs like sertraline play a crucial role in managing depression and anxiety, this case report highlights the importance of awareness and caution due to the potential risk of severe side effects such as acute pancreatitis. Both healthcare professionals and patients must work together to balance the benefits of antidepressant therapy with the vigilance required to mitigate risks, ensuring the safe and effective use of these essential medications.