In the relentless battle against high-grade glioma, a formidable foe within the realm of central nervous system tumors, the quest for effective treatments continues unabated. Amidst this search, anlotinib emerges as a promising ally, offering new hope to patients grappling with this aggressive cancer.

We will look into the recent findings on anlotinib’s efficacy and safety, aiming to illuminate its potential for patients and medical professionals.

Anlotinib: A Multifaceted Warrior

Anlotinib, a novel multi-kinase inhibitor, has carved out a niche for itself in treating various cancers, including non-small cell lung cancer and soft tissue sarcoma.

Its prowess lies in its ability to thwart tumor growth and angiogenesis, thereby mitigating edema—a common and challenging symptom in high-grade glioma management.

The spotlight on anlotinib has brightened following a retrospective analysis by a group of Chinese scientists scrutinizing its role in treating high-grade glioma alongside insights from a study on small-cell lung cancer with brain metastases.

A Glimpse into the Study’s Heart

The study encompassed 26 patients with newly diagnosed or recurrent high-grade gliomas treated with anlotinib alongside or post-chemoradiotherapy from 2017 to 2022.

The outcomes were promising: a disease control rate of 96.2% and an overall response rate of 73.1%. The median progression-free survival (PFS) spanned 8.9 months, with a 6-month PFS rate of 72.5%.

Moreover, the median overall survival (OS) reached 12 months, with a 12-month OS rate of 42.6%. These figures underscore anlotinib’s potential in extending both PFS and OS, with most adverse effects being mild (grades 1–2), highlighting its safety profile.

The Synergy of Anlotinib and Chemoradiotherapy

The Synergy of Anlotinib and Chemoradiotherapy - Safe Therapeutics LLC

The study’s findings illuminate anlotinib’s efficacy as a standalone treatment and in synergy with chemoradiotherapy. This combination has significantly prolonged survival, offering a glimmer of hope for those battling high-grade gliomas. The safety profile of anlotinib, characterized by manageable adverse effects, further bolsters its appeal as a viable treatment option.

Bridging Insights from Lung Cancer Treatment

Complementing the findings from Shen et al.’s study, research on anlotinib’s use in small-cell lung cancer with brain metastases reveals its broader therapeutic potential.

Combining anlotinib with immune checkpoint inhibitors has demonstrated significant benefits in progression-free and intracranial survival without introducing severe adverse effects.

This suggests that anlotinib’s utility might extend beyond gliomas, offering a new therapeutic avenue for cancers with brain metastases.

The Road Ahead

While the studies on anlotinib offer promising insights, they also underscore the necessity for further research. The quest for more effective, less toxic cancer treatments is ongoing, and anlotinib’s role in this journey is undeniably significant.

For patients battling high-grade glioma and other cancers, anlotinib represents not just a treatment option but a beacon of hope—a potential path to longer, better-quality lives.


As the medical community continues to explore and refine cancer treatments, anlotinib stands out as a promising candidate in the fight against high-grade glioma and beyond. Its ability to improve survival rates while maintaining a favorable safety profile makes it a noteworthy addition to the oncologist’s arsenal.

For patients facing the daunting diagnosis of high-grade glioma, advancements like these offer not just hope for survival but also the promise of a future where cancer’s grip is significantly loosened.